Anti-Human MICA/B Recombinant Antibody (SAA0346), APC (HS894237)

Name: Anti-Human MICA/B Recombinant Antibody (SAA0346), APC
Brand: abinScience
SKU: HS894237
Price: 290 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호	HS894237
종 반응성	Human
응용 분야	ELISA, FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	SAA0346
접합	APC
타겟	MHC class I polypeptide-related sequence A, MIC-A, MICA, PERB11.1, MHC class I polypeptide-related sequence B, MIC-B, MICB, PERB11.2
내독소 수준	Please contact with the lab for this information.
관련 제품	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
등록번호	Q29983, Q29980
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	MHC class I polypeptide-related sequence A (MICA/MICB) is a ~42 kDa protein. Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. 1. Steinle, A. et al. (2001) Immunogenetics 53, 279-87. PMID: 11491531 2. Sutherland, CL. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 671-9. PMID: 11777960 3. Bauer, S. et al. (1999) Science (New York, N.Y.) 285, 727-9. PMID: 10426993
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.