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| 카탈로그 번호 | HY526013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1516 | ||||
| 타겟 | SL-1, Transin-1, MMP-3, MMP3, Matrix metalloproteinase-3, Stromelysin-1, STMY1 | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P08254 | ||||
| RRID | Anti-Human MMP3 Antibody (SAA1516) (abinScience Cat# HY526013, RRID:AB_3727277) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Stromelysin-1 (MMP3) is a ~53 kDa protein. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. 1. Arza, B. et al. (2000) European journal of biochemistry 267, 6378-84. PMID: 11029580 2. Ogata, Y. et al. (1992) The Journal of biological chemistry 267, 3581-4. PMID: 1371271 3. Nagase, H. et al. (1990) Biochemistry 29, 5783-9. PMID: 2383557 4. Shin, EJ. et al. (2012) Neurochemistry international 60, 249-56. PMID: 22265821 5. Choi, DH. et al. (2011) The Journal of biological chemistry 286, 14168-77. PMID: 21330369 6. Feng, T. et al. (2022) Antiviral research 206, 105388. PMID: 35940311 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human MMP3 Antibody (SAA1516)
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