中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HW551025 |
|---|---|
| 설명 |
Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025) is a mouse monoclonal antibody detecting GPX4. Suitable for Human, Mouse, and Rat.
Highlights
|
| 종 반응성 | Human, Mouse, Rat |
| 응용 분야 | ELISA, WB |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2b |
| 클론 ID | 1A726 |
| 면역원 | E. coli - derived recombinant rat GPX4 (Gly73-Leu196). |
| 타겟 | EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 관찰된 분자량 | 20 kDa |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P36970 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735 |
| 참고사항 | For research use only |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
