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| 카탈로그 번호 | HP178013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a | ||||
| 클론 ID | SAA0253 | ||||
| 타겟 | hPCl2, Metal-response element-binding transcription factor 2, Polycomb-like protein 2, PCL2, MTF2, Metal regulatory transcription factor 2, Metal-response element DNA-binding protein M96 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q9Y483 | ||||
| RRID | Anti-Human MTF2 IP Antibody (SAA0253) (abinScience Cat# HP178013, RRID:AB_3729787) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Metal-response element-binding transcription factor 2 (MTF2) is a ~67 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. 1. Musselman, CA. et al. (2012) Nature structural & molecular biology 19, 1266-72. PMID: 23142980 2. Qin, S. et al. (2013) Biochemical and biophysical research communications 430, 547-53. PMID: 23228662 3. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human MTF2 IP Antibody (SAA0253)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
