Anti-Human NLRX1 Polyclonal Antibody (HP387014)

Name: Anti-Human NLRX1 Polyclonal Antibody
Brand: abinScience
SKU: HP387014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HP387014

설명

Anti-Human NLRX1 Polyclonal Antibody (HP387014) is a rabbit polyclonal antibody detecting NLRX1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human NLRX1 (Arg667-Ser975).

타겟

NLR family member X1, NOD5, Caterpiller protein 11.3, NOD9, Nucleotide-binding oligomerization domain protein 9, NLRX1, Nucleotide-binding oligomerization domain protein 26, Nucleotide-binding oligomerization domain protein 5, NOD26, CLR11.3

정제

Purified by antigen affinity column.

등록번호

Q86UT6

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

NLR family member X1 (NLRX1) is a ~107 kDa protein. Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species.

1. Moore, CB. et al. (2008) Nature 451, 573-7. PMID: 18200010

2. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352

3. Li, H. et al. (2016) Molecular immunology 76, 90-7. PMID: 27393910

4. Tattoli, I. et al. (2008) EMBO reports 9, 293-300. PMID: 18219313

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human NLRX1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human NLRX1 Polyclonal Antibody (HP387014)

개요

이미지

참고 문헌

데이터시트

SDS