中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HW388147 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0105 |
| 접합 | PerCP |
| 타겟 | Nitric oxide synthase, inducible, NOS2A, Inducible NO synthase, HEP-NOS, Hepatocyte NOS, Peptidyl-cysteine S-nitrosylase NOS2, iNOS, NOS2, Inducible NOS, NOS type II |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), PerCP |
| 등록번호 | P35228 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Nitric oxide synthase, inducible (NOS2/iNOS) is a ~131 kDa protein. Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8. 1. Charles, IG. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11419-23. PMID: 7504305 2. Hokari, A. et al. (1994) Journal of biochemistry 116, 575-81. PMID: 7531687 3. Guo, FH. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7809-13. PMID: 7544004 4. Geller, DA. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 3491-5. PMID: 7682706 5. Jia, J. et al. (2014) Cell 159, 623-34. PMID: 25417112 6. Vuolteenaho, K. et al. (2009) Mediators of inflammation 2009, 345838. PMID: 19688109 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
