Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105) (HW388107)

Name: Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105)
Brand: abinScience
SKU: HW388107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HW388107
Species reactivity	Human
Applications	FCM, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0105
Clonality	Monoclonal
Target	Nitric oxide synthase, inducible, NOS2A, Inducible NO synthase, HEP-NOS, Hepatocyte NOS, Peptidyl-cysteine S-nitrosylase NOS2, iNOS, NOS2, Inducible NOS, NOS type II
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P35228
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Nitric oxide synthase, inducible (NOS2/iNOS) is a ~131 kDa protein. Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8. 1. Charles, IG. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11419-23. PMID: 7504305 2. Hokari, A. et al. (1994) Journal of biochemistry 116, 575-81. PMID: 7531687 3. Guo, FH. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7809-13. PMID: 7544004 4. Geller, DA. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 3491-5. PMID: 7682706 5. Jia, J. et al. (2014) Cell 159, 623-34. PMID: 25417112 6. Vuolteenaho, K. et al. (2009) Mediators of inflammation 2009, 345838. PMID: 19688109
Note	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human NOS2/iNOS Antibody (SAA0105)
Western blot

Western blot analysis was performed using anti-INOS monoclonal antibody at 1ug/mL on various samples.
Lane 1: RAW264.7 cell lystae
Lane 2: RAW264.7+LPS cell lystae

References

Datasheet

Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105).pdf

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Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105) (HW388107)

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