Anti-Human NOTCH3 Polyclonal Antibody (HV701014)

Name: Anti-Human NOTCH3 Polyclonal Antibody
Brand: abinScience
SKU: HV701014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HV701014

설명

Anti-Human NOTCH3 Polyclonal Antibody (HV701014) is a rabbit polyclonal antibody detecting NOTCH3. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human NOTCH3 (Ala40-Glu467).

타겟

NOTCH3, Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q9UM47

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Neurogenic locus notch homolog protein 3 (NOTCH3) is a ~243 kDa protein. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

1. Peters, N. et al. (2004) Experimental cell research 299, 454-64. PMID: 15350543

2. Joutel, A. et al. (2004) American journal of human genetics 74, 338-47. PMID: 14714274

참고사항

For research use only

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