Anti-Human Notch-3 Reference Antibody (PF-06650808, RUO) (HV701016)

Name: Anti-Human Notch-3 Reference Antibody (PF-06650808, RUO)
Brand: abinScience
SKU: HV701016
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HV701016
Description	Anti-Human NOTCH3 (PF-06650808) (HV701016) is a research-grade recombinant antibody targeting Neurogenic locus notch homolog protein 3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	PF-06650808
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9UM47
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	PF-06650808, PF06650808, PF06650808
Background	Neurogenic locus notch homolog protein 3 (NOTCH3) is a ~243 kDa protein. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD), it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. 1. Peters, N. et al. (2004) Experimental cell research 299, 454-64. PMID: 15350543 2. Joutel, A. et al. (2004) American journal of human genetics 74, 338-47. PMID: 14714274
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human NOTCH3 (PF-06650808)

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Anti-Human Notch-3 Reference Antibody (PF-06650808, RUO).pdf

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Anti-Human Notch-3 Reference Antibody (PF-06650808, RUO) (HV701016)

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