Anti-Human NPRL3 Polyclonal Antibody (HD550014)

Name: Anti-Human NPRL3 Polyclonal Antibody
Brand: abinScience
SKU: HD550014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD550014

설명

Anti-Human NPRL3 Polyclonal Antibody (HD550014) is a rabbit polyclonal antibody detecting NPRL3. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human NPRL3 (Met1-Pro569).

타겟

-14 gene protein, Alpha-globin regulatory element-containing gene protein, C16orf35, CGTHBA, GATOR1 complex protein NPRL3, MARE, NPRL3, Nitrogen permease regulator 3-like protein, Protein CGTHBA

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q12980

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

GATOR1 complex protein NPRL3 is a ~63 kDa protein. As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway.

1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238

2. Shen, K. et al. (2018) Nature 556, 64-69. PMID: 29590090

3. Egri, SB. et al. (2022) Molecular cell 82, 1836-1849.e5. PMID: 35338845

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human NPRL3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human NPRL3 Polyclonal Antibody (HD550014)

개요

이미지

참고 문헌

데이터시트

SDS