Anti-Human OTUD7B Polyclonal Antibody (HC193014)

Name: Anti-Human OTUD7B Polyclonal Antibody
Brand: abinScience
SKU: HC193014
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HC193014

설명

Anti-Human OTUD7B Polyclonal Antibody (HC193014) is a rabbit polyclonal antibody detecting OTUD7B. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human OTUD7B (Gln136-Ser438).

타겟

Cellular zinc finger anti-NF-kappa-B protein, Cezanne, EC:3.4.19.12, OTU domain-containing protein 7B, OTUD7B, ZA20D1, Zinc finger A20 domain-containing protein 1, Zinc finger protein Cezanne

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q6GQQ9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

OTU domain-containing protein 7B (OTUD7B) is a ~92 kDa protein. Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2.

1. Enesa, K. et al. (2008) The Journal of biological chemistry 283, 7036-45. PMID: 18178551

2. Hu, H. et al. (2016) The Journal of experimental medicine 213, 399-414. PMID: 26903241

3. Pareja, F. et al. (2012) Oncogene 31, 4599-608. PMID: 22179831

4. Evans, PC. et al. (2001) The Biochemical journal 357, 617-23. PMID: 11463333

5. Bremm, A. et al. (2010) Nature structural & molecular biology 17, 939-47. PMID: 20622874

6. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681

7. Mevissen, TET. et al. (2016) Nature 538, 402-405. PMID: 27732584

8. Evans, PC. et al. (2003) The Journal of biological chemistry 278, 23180-6. PMID: 12682062

9. Wang, B. et al. (2017) Nature 545, 365-369. PMID: 28489822

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human OTUD7B Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human OTUD7B Polyclonal Antibody (HC193014)

개요

이미지

참고 문헌

데이터시트

SDS