Anti-Human PABPC1 Polyclonal Antibody (HY439014)

Name: Anti-Human PABPC1 Polyclonal Antibody
Brand: abinScience
SKU: HY439014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HY439014

설명

Anti-Human PABPC1 Polyclonal Antibody (HY439014) is a rabbit polyclonal antibody detecting PABPC1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PABPC1 (Met10-Arg390).

타겟

PABP-1, PAB1, PABPC2, PABPC1, Polyadenylate-binding protein 1, Poly(A)-binding protein 1, PABP1

정제

Purified by antigen affinity column.

등록번호

P11940

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Polyadenylate-binding protein 1 (PABPC1) is a ~70 kDa protein. Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover.

1. Grosset, C. et al. (2000) Cell 103, 29-40. PMID: 11051545

2. Patel, GP. et al. (2006) The FEBS journal 273, 5678-90. PMID: 17212783

3. Lim, J. et al. (2014) Cell 159, 1365-76. PMID: 25480299

4. Schäffler, K. et al. (2010) RNA (New York, N.Y.) 16, 1488-99. PMID: 20573744

5. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947

6. Singh, G. et al. (2008) PLoS biology 6, e111. PMID: 18447585

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human PABPC1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human PABPC1 Polyclonal Antibody (HY439014)

개요

이미지

참고 문헌

데이터시트

SDS

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