中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HS822013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1680 | ||||
| 타겟 | PDHK1, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, PDK1, Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q15118 | ||||
| RRID | Anti-Human PDK1 Antibody (SAA1680) (abinScience Cat# HS822013, RRID:AB_3727441) |
||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) is a ~49 kDa protein. Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. 1. Gudi, R. et al. (1995) The Journal of biological chemistry 270, 28989-94. PMID: 7499431 2. McFate, T. et al. (2008) The Journal of biological chemistry 283, 22700-8. PMID: 18541534 3. Hitosugi, T. et al. (2011) Molecular cell 44, 864-77. PMID: 22195962 4. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675 5. Kato, M. et al. (2007) Structure (London, England : 1993) 15, 992-1004. PMID: 17683942 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human PDK1 Antibody (SAA1680)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
