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| 카탈로그 번호 | HF951023 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG4, kappa | ||||
| 클론 ID | 1F36 | ||||
| 타겟 | Peptidoglycan recognition protein 1, PGLYRP, PGRP, Peptidoglycan recognition protein short, TNFSF3L, PGRP-S, PGLYRP1 | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O75594 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Peptidoglycan recognition protein 1 (PGLYRP1) is a ~21 kDa protein. Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. 1. Kang, D. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 10078-82. PMID: 9707603 2. Yashin, DV. et al. (2011) The Journal of biological chemistry 286, 10258-64. PMID: 21247889 3. Yashin, DV. et al. (2015) The Journal of biological chemistry 290, 21724-31. PMID: 26183779 4. Dukhanina, EA. et al. (2015) Cell cycle (Georgetown, Tex.) 14, 3635-43. PMID: 26654597 5. Sharapova, TN. et al. (2018) Acta naturae 10, 115-120. PMID: 30713770 6. Sharapova, TN. et al. (2017) Journal of innate immunity 9, 598-608. PMID: 28977785 7. Sharapova, TN. et al. (2017) IUBMB life 69, 971-977. PMID: 29083508 8. Read, CB. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 194, 1417-21. PMID: 25595774 | ||||
| 참고사항 | For research use only. | ||||
| Isotype Control | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207) |
SDS-PAGE for Anti-Human PGLYRP1 Antibody (1F36)
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