Anti-Human PIP4K2A Polyclonal Antibody (HD637014)

Name: Anti-Human PIP4K2A Polyclonal Antibody
Brand: abinScience
SKU: HD637014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD637014

설명

Anti-Human PIP4K2A Polyclonal Antibody (HD637014) is a rabbit polyclonal antibody detecting PIP4K2A. Suitable for Human, Rat, and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human PIP4K2A (Ser34-Thr406).

타겟

1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha, Diphosphoinositide kinase 2-alpha, EC:2.7.1.149, PI(5)P 4-kinase type II alpha, PI5P4KA, PI5P4Kalpha, PIP4K2A, PIP4KII-alpha, PIP5K2, PIP5K2A, PIP5KIII, Phosphatidylinositol 5-Phosphate 4-Kinase, Phosphatidylinositol 5-phosphate 4-kinase type II alpha, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, PtdIns(4)P-5-kinase B isoform, PtdIns(4)P-5-kinase C isoform, PtdIns(5)P-4-kinase isoform 2-alpha

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P48426

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

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제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a ~46 kDa protein. Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level.

1. Davis, MI. et al. (2013) PloS one 8, e54127. PMID: 23326584

2. Rameh, LE. et al. (1997) Nature 390, 192-6. PMID: 9367159

3. Sumita, K. et al. (2016) Molecular cell 61, 187-98. PMID: 26774281

4. Wilcox, A. et al. (2008) FEBS letters 582, 1391-4. PMID: 18364242

5. Hu, A. et al. (2018) Journal of lipid research 59, 507-514. PMID: 29353240

6. Wang, DG. et al. (2019) Cell reports 27, 1991-2001.e5. PMID: 31091439

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human PIP4K2A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human PIP4K2A Polyclonal Antibody (HD637014)

개요

이미지

참고 문헌

데이터시트

SDS