Anti-Human POLD4 Polyclonal Antibody (HD558014)

Name: Anti-Human POLD4 Polyclonal Antibody
Brand: abinScience
SKU: HD558014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD558014

설명

Anti-Human POLD4 Polyclonal Antibody (HD558014) is a rabbit polyclonal antibody detecting POLD4. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human POLD4 (Glu45-Leu107).

타겟

DNA polymerase delta subunit 4, DNA polymerase delta subunit p12, POLD4, POLDS

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q9HCU8

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

DNA polymerase delta subunit 4 (POLD4) is a ~12 kDa protein. As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb. Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites.

1. Li, H. et al. (2006) The Journal of biological chemistry 281, 14748-55. PMID: 16510448

2. Meng, X. et al. (2009) Nucleic acids research 37, 647-57. PMID: 19074196

3. Meng, X. et al. (2010) Biochemistry 49, 3545-54. PMID: 20334433

4. Lin, SH. et al. (2013) DNA repair 12, 922-35. PMID: 24035200

5. Costantino, L. et al. (2014) Science (New York, N.Y.) 343, 88-91. PMID: 24310611

6. Terai, K. et al. (2013) The Journal of biological chemistry 288, 30509-30514. PMID: 24022480

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human POLD4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human POLD4 Polyclonal Antibody (HD558014)

개요

이미지

참고 문헌

데이터시트

SDS