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| 카탈로그 번호 | HT002014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human PRMT3 Polyclonal Antibody (HT002014) is a rabbit polyclonal antibody detecting PRMT3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human PRMT3 (Leu212-Gln531). | ||||||||
| 타겟 | Protein arginine N-methyltransferase 3, 2.1.1.319, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3, PRMT3, HRMT1L3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O60678 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein arginine N-methyltransferase 3 (PRMT3) is a ~59 kDa protein. Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases. Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2. Also appears to methylate other ribosomal proteins. May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation. 1. Siarheyeva, A. et al. (2012) Structure (London, England : 1993) 20, 1425-35. PMID: 22795084 2. Liu, F. et al. (2013) Journal of medicinal chemistry 56, 2110-24. PMID: 23445220 3. Kaniskan, HÜ. et al. (2015) Angewandte Chemie (International ed. in English) 54, 5166-70. PMID: 25728001 4. Min, Z. et al. (2019) Cell death & disease 10, 581. PMID: 31378783 5. Verma, M. et al. (2021) Communications biology 4, 109. PMID: 33495566 6. Gupta, S. et al. (2024) The Biochemical journal 481, 1723-1740. PMID: 39513743 | ||||||||
| 참고사항 | For research use only. |
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