中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HW821013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1783 | ||||
| 타겟 | PSEN2, PS-2, AD4, PS2, AD3LP, STM2, E5-1, STM-2, Presenilin-2, AD5, PSNL2 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P49810 | ||||
| RRID | Anti-Human PSEN2/Presenilin-2 Antibody (SAA1783) (abinScience Cat# HW821013, RRID:AB_3727545) |
||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. 1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236 2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302 3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394 4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189 5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978 6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576 7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human PSEN2/Presenilin-2 Antibody (SAA1783)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
