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| 카탈로그 번호 | HP909014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RBCK1 (Met1-Gly156). | ||||||||
| 타겟 | RING finger protein 54, RNF54, RanBP-type and C3HC4-type zinc finger-containing protein 1, C20orf18, XAP4 X-associated protein 4, UBCE7IP3, RBCK1, RING-type E3 ubiquitin transferase HOIL-1, HOIL-1, Heme-oxidized IRP2 ubiquitin ligase 1, XAP3, Ubiquitin-conjugating enzyme 7-interacting protein 3, HBV-associated factor 4 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9BYM8 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) is a ~57 kDa protein. E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. 1. Yamanaka, K. et al. (2003) Nature cell biology 5, 336-40. PMID: 12629548 2. Tian, Y. et al. (2007) The Journal of biological chemistry 282, 16776-82. PMID: 17449468 3. Zhang, M. et al. (2008) Cell research 18, 1096-104. PMID: 18711448 4. Kirisako, T. et al. (2006) The EMBO journal 25, 4877-87. PMID: 17006537 5. Tokunaga, F. et al. (2009) Nature cell biology 11, 123-32. PMID: 19136968 6. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173 7. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180 8. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181 9. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331 | ||||||||
| 참고사항 | For research use only. |
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