Anti-Human RCC1 Polyclonal Antibody (HD651014)

Name: Anti-Human RCC1 Polyclonal Antibody
Brand: abinScience
SKU: HD651014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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개요

카탈로그 번호

HD651014

설명

Anti-Human RCC1 Polyclonal Antibody (HD651014) is a rabbit polyclonal antibody detecting RCC1. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RCC1 (Val37-Ser421).

타겟

CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P18754

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Regulator of chromosome condensation (RCC1) is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.

1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674

2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751

3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575

4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449

5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983

6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532

7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human RCC1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human RCC1 Polyclonal Antibody (HD651014)

개요

이미지

참고 문헌

데이터시트

SDS