中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HC711014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human RNF31 Polyclonal Antibody (HC711014) is a rabbit polyclonal antibody detecting RNF31. Suitable for Human.
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human RNF31 (Met1-Lys181). | ||||||||
| 타겟 | E3 ubiquitin-protein ligase RNF31, EC:2.3.2.31, HOIL-1-interacting protein, HOIP, RING finger protein 31, RING-type E3 ubiquitin transferase RNF31, RNF31, ZIBRA, Zinc in-between-RING-finger ubiquitin-associated domain protein | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q96EP0 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 배경 | E3 ubiquitin-protein ligase RNF31 is a ~119 kDa protein. E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. 1. Kirisako, T. et al. (2006) The EMBO journal 25, 4877-87. PMID: 17006537 2. Tokunaga, F. et al. (2009) Nature cell biology 11, 123-32. PMID: 19136968 3. Haas, TL. et al. (2009) Molecular cell 36, 831-44. PMID: 20005846 4. Gerlach, B. et al. (2011) Nature 471, 591-6. PMID: 21455173 5. Tokunaga, F. et al. (2011) Nature 471, 633-6. PMID: 21455180 6. Ikeda, F. et al. (2011) Nature 471, 637-41. PMID: 21455181 7. Smit, JJ. et al. (2012) The EMBO journal 31, 3833-44. PMID: 22863777 8. Goto, E. et al. (2017) Biochemical and biophysical research communications 485, 152-159. PMID: 28189684 9. Noad, J. et al. (2017) Nature microbiology 2, 17063. PMID: 28481331 10. Schlicher, L. et al. (2016) EMBO reports 17, 1485-1497. PMID: 27458237 | ||||||||
| 참고사항 | For research use only |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
