

| 카탈로그 번호 | HF745014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human SASH1 Polyclonal Antibody (HF745014) is a rabbit polyclonal antibody detecting SASH1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SASH1 (Val1091-Met1247). | ||||||||
| 타겟 | SAM and SH3 domain-containing protein 1, Proline-glutamate repeat-containing protein, SASH1, KIAA0790, PEPE1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O94885 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | SAM and SH3 domain-containing protein 1 (SASH1) is a ~136 kDa protein. Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. 1. Dauphinee, SM. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 892-901. PMID: 23776175 2. Zhou, D. et al. (2013) Cellular signalling 25, 1526-38. PMID: 23333244 3. Courcet, JB. et al. (2015) European journal of human genetics : EJHG 23, 957-62. PMID: 25315659 | ||||||||
| 참고사항 | For research use only. |
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