Anti-Human SENP1 Polyclonal Antibody (HP578014)

Name: Anti-Human SENP1 Polyclonal Antibody
Brand: abinScience
SKU: HP578014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HP578014

설명

Anti-Human SENP1 Polyclonal Antibody (HP578014) is a rabbit polyclonal antibody detecting SENP1 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human SENP1 (Glu422-Leu644).

타겟

Sentrin/SUMO-specific protease SENP1, SENP1, Sentrin-specific protease 1

정제

Purified by antigen affinity column.

등록번호

Q9P0U3

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Sentrin-specific protease 1 (SENP1) is a ~73 kDa protein. Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity.

1. Gong, L. et al. (2000) The Journal of biological chemistry 275, 3355-9. PMID: 10652325

2. Cheng, J. et al. (2004) Molecular and cellular biology 24, 6021-8. PMID: 15199155

3. Xu, Z. et al. (2005) The Biochemical journal 386, 325-30. PMID: 15487983

4. Kim, YH. et al. (2005) FEBS letters 579, 6272-8. PMID: 16253240

5. Shen, LN. et al. (2006) The Biochemical journal 397, 279-88. PMID: 16553580

6. Hong, Y. et al. (2011) PloS one 6, e23046. PMID: 21829689

7. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678

8. Li, S. et al. (2013) Oncogene 32, 4883-91. PMID: 23160374

9. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 24943844

10. Park, JH. et al. (2014) Nature communications 5, 5483. PMID: 25406032

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human SENP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human SENP1 Polyclonal Antibody (HP578014)

개요

이미지

참고 문헌

데이터시트

SDS