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| 카탈로그 번호 | HT245013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||
| 응용 분야 | ELISA, IF, IP | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1 | ||||
| 클론 ID | SAA0228 | ||||
| 타겟 | PRMT5, SKB1 homolog, 72 kDa ICln-binding protein, Jak-binding protein 1, Histone-arginine N-methyltransferase PRMT5, SKB1Hs, JBP1, Shk1 kinase-binding protein 1 homolog, SKB1, HRMT1L5, IBP72, Protein arginine N-methyltransferase 5 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O14744 | ||||
| RRID | Anti-Human SKB1/PRMT5 IP Antibody (SAA0228) (abinScience Cat# HT245013, RRID:AB_3729762) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Protein arginine N-methyltransferase 5 (SKB1/PRMT5) is a ~72 kDa protein. Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties. May methylate the N-terminal region of MBD2. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. 1. Pollack, BP. et al. (1999) The Journal of biological chemistry 274, 31531-42. PMID: 10531356 2. Rho, J. et al. (2001) The Journal of biological chemistry 276, 11393-401. PMID: 11152681 3. Meister, G. et al. (2001) Current biology : CB 11, 1990-4. PMID: 11747828 4. Meister, G. et al. (2002) The EMBO journal 21, 5853-63. PMID: 12411503 5. Jiang, W. et al. (2005) Biochemical and biophysical research communications 329, 522-30. PMID: 15737618 6. Gonsalvez, GB. et al. (2007) The Journal of cell biology 178, 733-40. PMID: 17709427 7. Ren, J. et al. (2010) The Journal of biological chemistry 285, 12695-705. PMID: 20159986 8. Guo, S. et al. (2010) The Journal of biological chemistry 285, 35133-41. PMID: 20810653 9. Guderian, G. et al. (2011) The Journal of biological chemistry 286, 1976-86. PMID: 21081503 10. Hsu, JM. et al. (2011) Nature cell biology 13, 174-81. PMID: 21258366 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human SKB1/PRMT5 IP Antibody (SAA0228)
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