Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667) (HB725035)

Name: Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667)
Brand: abinScience
SKU: HB725035
Price: 106 USD
Availability: InStock

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개요

카탈로그 번호	HB725035
설명	Anti-Human SLC6A4 Monoclonal Antibody (1A667) [1A667] (HB725035) is a mouse monoclonal antibody detecting SLC6A4 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG
클론 ID	1A667
면역원	E. coli - derived recombinant human SLC6A4 (Ala181-Ser252).
타겟	Sodium-dependent serotonin transporter, SERT, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P31645
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Sodium-dependent serotonin transporter (SLC6A4) is a ~70 kDa protein. Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling. Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse. 1. Mortensen, OV. et al. (1999) Brain research. Molecular brain research 71, 120-6. PMID: 10407194 2. Kilic, F. et al. (2003) Molecular pharmacology 64, 440-6. PMID: 12869649 3. Henry, LK. et al. (2011) The Journal of biological chemistry 286, 30823-30836. PMID: 21730057 4. Coleman, JA. et al. (2016) Nature 532, 334-9. PMID: 27049939 5. Hasenhuetl, PS. et al. (2016) The Journal of biological chemistry 291, 25864-25876. PMID: 27756841 6. Yang, D. et al. (2021) Science advances 7, eabl3857. PMID: 34851672 7. Brenner, B. et al. (2007) Journal of neurochemistry 102, 206-15. PMID: 17506858 8. Carneiro, AM. et al. (2008) The Journal of clinical investigation 118, 1544-52. PMID: 18317590
참고사항	For research use only.

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SDS-PAGE for Anti-Human SLC6A4 Monoclonal Antibody (1A667)

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Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667).pdf

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Anti-Human SLC6A4/SERT Monoclonal Antibody (1A667) (HB725035)

개요

이미지

참고 문헌

데이터시트

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