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| 카탈로그 번호 | HV066147 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | SAA0179 |
| 접합 | PerCP |
| 타겟 | Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3 |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PerCP |
| 등록번호 | Q99523 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Sortilin (SORT1/Gp95) is a ~92 kDa protein. Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. 1. Ni, X. et al. (2006) Traffic (Copenhagen, Denmark) 7, 889-902. PMID: 16787399 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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