Anti-Human Sortilin Reference Antibody (Latozinemab, RUO) (HV066016)

Name: Anti-Human Sortilin Reference Antibody (Latozinemab, RUO)
Brand: abinScience
SKU: HV066016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HV066016
Description	Latozinemab (HV066016) is a research-grade recombinant antibody targeting Neurotensin receptor 3. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-Kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q99523
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AL001, 2376132-27-1
Background	Sortilin (SORT1/Gp95) is a ~92 kDa protein. Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. 1. Ni, X. et al. (2006) Traffic (Copenhagen, Denmark) 7, 889-902. PMID: 16787399
Note	For research use only. Not suitable for clinical or therapeutic use.

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Datasheet

Anti-Human Sortilin Reference Antibody (Latozinemab, RUO).pdf

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Anti-Human Sortilin Reference Antibody (Latozinemab, RUO) (HV066016)

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