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| 카탈로그 번호 | HP400014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human SRP68 (Met293-Gln540). | ||||||||
| 타겟 | Signal recognition particle 68 kDa protein, Signal recognition particle subunit SRP68, SRP68 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9UHB9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Signal recognition particle subunit SRP68 is a ~70 kDa protein. Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently. The SRP complex possibly participates in the elongation arrest function. 1. Lee, JH. et al. (2021) Science advances 7. PMID: 34020957 2. Iakhiaeva, E. et al. (2006) Protein science : a publication of the Protein Society 15, 1290-302. PMID: 16672232 3. Becker, MM. et al. (2017) Nucleic acids research 45, 470-481. PMID: 27899666 | ||||||||
| 참고사항 | For research use only. |
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