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| 카탈로그 번호 | HF005014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TDP2 (Gly111-Leu362). | ||||||||
| 타겟 | Tyr-DNA phosphodiesterase 2, TDP2, hTDP2, 5'-tyrosyl-DNA phosphodiesterase, Tyrosyl-DNA phosphodiesterase 2, EAP2, Tyrosyl-RNA phosphodiesterase, EAPII, TTRAP, VPg unlinkase, 5'-Tyr-DNA phosphodiesterase, TRAF and TNF receptor-associated protein, ETS1-associated protein II, ETS1-associated protein 2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95551 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a ~40 kDa protein. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. 1. Schellenberg, MJ. et al. (2016) Nucleic acids research 44, 3829-44. PMID: 27060144 2. Hornyak, P. et al. (2016) The Biochemical journal 473, 1869-79. PMID: 27099339 | ||||||||
| 참고사항 | For research use only. |
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