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| 카탈로그 번호 | HV815014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TICAM1 Polyclonal Antibody (HV815014) is a rabbit polyclonal antibody detecting TICAM1. Suitable for Human.
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TICAM1 (Met1-Cys144). | ||||||||
| 타겟 | MyD88-3, PRVTIRB, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, TICAM-1, TICAM1, TIR domain-containing adapter molecule 1, TIR domain-containing adapter protein inducing IFN-beta, TRIF, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8IUC6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | TIR domain-containing adapter molecule 1 (TICAM1) is a ~76 kDa protein. Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. 1. Yamamoto, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 6668-72. PMID: 12471095 2. Oshiumi, H. et al. (2003) Nature immunology 4, 161-7. PMID: 12539043 3. Han, KJ. et al. (2004) The Journal of biological chemistry 279, 15652-61. PMID: 14739303 4. Ye, W. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 1856-1864. PMID: 28747347 5. Pallett, MA. et al. (2022) Viruses 14. PMID: 35215908 6. Liu, S. et al. (2015) Science (New York, N.Y.) 347, aaa2630. PMID: 25636800 | ||||||||
| 참고사항 | For research use only |
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