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| 카탈로그 번호 | HS891023 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human TM4SF20 Recombinant Antibody (66B12) (HS891023) is a mouse monoclonal antibody detecting TM4SF20 in ELISA. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | 66B12 | ||||
| 타겟 | Transmembrane 4 L6 family member 20, TM4SF20 | ||||
| 내독소 수준 | < 10 EU/mg as determined by LAL method. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q53R12 | ||||
| RRID | Anti-Human TM4SF20 Antibody (66B12) (abinScience Cat# HS891023, RRID:AB_3729627) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Transmembrane 4 L6 family member 20 (TM4SF20) is a ~25 kDa protein. Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. 1. Chen, Q. et al. (2014) PloS one 9, e108528. PMID: 25310401 2. Chen, Q. et al. (2016) Molecular cell 63, 567-578. PMID: 27499293 | ||||
| 참고사항 | For research use only. | ||||
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for Anti-Human TM4SF20 Antibody (66B12)
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