Anti-Human TMEM59 Polyclonal Antibody (HD403014)

Name: Anti-Human TMEM59 Polyclonal Antibody
Brand: abinScience
SKU: HD403014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HD403014

설명

Anti-Human TMEM59 Polyclonal Antibody (HD403014) is a rabbit polyclonal antibody detecting TMEM59. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TMEM59 (Gly45-Val135).

타겟

C1orf8, Liver membrane-bound protein, TMEM59, Transmembrane protein 59

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q9BXS4

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Transmembrane protein 59 (TMEM59) is a ~36 kDa protein. Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.

1. Boada-Romero, E. et al. (2013) The EMBO journal 32, 566-82. PMID: 23376921

2. Boada-Romero, E. et al. (2016) Nature communications 7, 11821. PMID: 27273576

3. Ullrich, S. et al. (2010) The Journal of biological chemistry 285, 20664-74. PMID: 20427278

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human TMEM59 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TMEM59 Polyclonal Antibody (HD403014)

개요

이미지

참고 문헌

데이터시트

SDS