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| 카탈로그 번호 | HX932013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1977 | ||||
| 타겟 | TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, Tumor necrosis factor alpha-induced protein 6, Hyaluronate-binding protein, TSG6, Tumor necrosis factor-inducible gene 6 protein, TNFAIP6, TSG-6 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P98066 | ||||
| RRID | Anti-Human TNFAIP6/TSG-6 Antibody (SAA1977) (abinScience Cat# HX932013, RRID:AB_3727741) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Tumor necrosis factor-inducible gene 6 protein (TNFAIP6/TSG-6) is a ~31 kDa protein. Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization. 1. Mahoney, DJ. et al. (2005) The Journal of biological chemistry 280, 27044-55. PMID: 15917224 2. Kuznetsova, SA. et al. (2008) Matrix biology : journal of the International Society for Matrix Biology 27, 201-10. PMID: 18042364 3. Lawrance, W. et al. (2016) The Journal of biological chemistry 291, 8014-30. PMID: 26823460 4. Forteza, R. et al. (2007) American journal of respiratory cell and molecular biology 36, 20-31. PMID: 16873769 5. Sanggaard, KW. et al. (2010) The Journal of biological chemistry 285, 21988-93. PMID: 20463016 6. Briggs, DC. et al. (2015) The Journal of biological chemistry 290, 28708-23. PMID: 26468290 7. Lesley, J. et al. (2004) The Journal of biological chemistry 279, 25745-54. PMID: 15060082 8. Dyer, DP. et al. (2016) The Journal of biological chemistry 291, 12627-12640. PMID: 27044744 10. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human TNFAIP6/TSG-6 Antibody (SAA1977)
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