Anti-Human TNFAIP6 Polyclonal Antibody (HX932014)

Name: Anti-Human TNFAIP6 Polyclonal Antibody
Brand: abinScience
SKU: HX932014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HX932014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TNFAIP6 (His26-Asp248).

Target

TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, Tumor necrosis factor alpha-induced protein 6, Hyaluronate-binding protein, TSG6, Tumor necrosis factor-inducible gene 6 protein, TNFAIP6, TSG-6

Purification

Purified by antigen affinity column.

Accession

P98066

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Tumor necrosis factor-inducible gene 6 protein (TNFAIP6/TSG-6) is a ~31 kDa protein. Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization.

1. Mahoney, DJ. et al. (2005) The Journal of biological chemistry 280, 27044-55. PMID: 15917224

2. Kuznetsova, SA. et al. (2008) Matrix biology : journal of the International Society for Matrix Biology 27, 201-10. PMID: 18042364

3. Lawrance, W. et al. (2016) The Journal of biological chemistry 291, 8014-30. PMID: 26823460

4. Forteza, R. et al. (2007) American journal of respiratory cell and molecular biology 36, 20-31. PMID: 16873769

5. Sanggaard, KW. et al. (2010) The Journal of biological chemistry 285, 21988-93. PMID: 20463016

6. Briggs, DC. et al. (2015) The Journal of biological chemistry 290, 28708-23. PMID: 26468290

7. Lesley, J. et al. (2004) The Journal of biological chemistry 279, 25745-54. PMID: 15060082

8. Dyer, DP. et al. (2016) The Journal of biological chemistry 291, 12627-12640. PMID: 27044744

10. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708

Note

For research use only.

Images

References

Datasheet

Anti-Human TNFAIP6 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human TNFAIP6 Polyclonal Antibody (HX932014)

Overview

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Datasheet

SDS

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