Anti-Human TRIB3 Polyclonal Antibody (HA514014)

Name: Anti-Human TRIB3 Polyclonal Antibody
Brand: abinScience
SKU: HA514014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HA514014

설명

Anti-Human TRIB3 Polyclonal Antibody (HA514014) is a rabbit polyclonal antibody detecting TRIB3 in ELISA, IHC, WB. Suitable for Bovine and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TRIB3 (Ser66-Gln317).

타겟

TRIB3

정제

Purified by antigen affinity column.

등록번호

Q96RU7

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Tribbles homolog 3, TRB-3, Neuronal cell death-inducible putative kinase, SINK, p65-interacting inhibitor of NF-kappa-B, TRIB3, C20orf97, NIPK, SKIP3, TRB3

배경

Tribbles homolog 3 (TRIB3) is a ~39 kDa protein. Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation.

1. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 15775988

2. Ord, D. et al. (2005) Biochemical and biophysical research communications 330, 210-8. PMID: 15781252

3. Wu, M. et al. (2003) The Journal of biological chemistry 278, 27072-9. PMID: 12736262

4. Kiss-Toth, E. et al. (2004) The Journal of biological chemistry 279, 42703-8. PMID: 15299019

5. Aynaud, MM. et al. (2012) The Journal of biological chemistry 287, 39182-92. PMID: 22977230

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-TRIB3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: LO2 cell lysate
Lane 2: PC-3 cell lysate

참고 문헌

데이터시트

Anti-Human TRIB3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TRIB3 Polyclonal Antibody (HA514014)

개요

이미지

참고 문헌

데이터시트

SDS