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| 카탈로그 번호 | HP111024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TRIM31 Polyclonal Antibody (HP111024) is a rabbit polyclonal antibody detecting TRIM31. Suitable for Human.
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TRIM31 (Met1-Gln145). | ||||||||
| 타겟 | C6orf13, E3 ubiquitin-protein ligase TRIM31, EC:2.3.2.27, RNF, TRIM31, Tripartite motif-containing protein 31 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9BZY9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | E3 ubiquitin-protein ligase TRIM31 is a ~48 kDa protein. E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth. 1. Sugiura, T. et al. (2008) Journal of cellular biochemistry 105, 1081-91. PMID: 18773414 2. Song, H. et al. (2016) Nature communications 7, 13727. PMID: 27929086 3. Liu, B. et al. (2017) Nature immunology 18, 214-224. PMID: 27992402 | ||||||||
| 참고사항 | For research use only |
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