Anti-Human TRIM31 Polyclonal Antibody (HP111014)

Name: Anti-Human TRIM31 Polyclonal Antibody
Brand: abinScience
SKU: HP111014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HP111014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TRIM31 (Ala2-Lys91).

Target

E3 ubiquitin-protein ligase TRIM31, TRIM31, Tripartite motif-containing protein 31, C6orf13, RNF, RING-type E3 ubiquitin transferase TRIM31

Purification

Purified by antigen affinity column.

Accession

Q9BZY9

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

E3 ubiquitin-protein ligase TRIM31 is a ~48 kDa protein. E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth.

1. Sugiura, T. et al. (2008) Journal of cellular biochemistry 105, 1081-91. PMID: 18773414

2. Song, H. et al. (2016) Nature communications 7, 13727. PMID: 27929086

3. Liu, B. et al. (2017) Nature immunology 18, 214-224. PMID: 27992402

Note

For research use only.

Images

References

Datasheet

Anti-Human TRIM31 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human TRIM31 Polyclonal Antibody (HP111014)

Overview

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References

Datasheet

SDS

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