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Anti-Human TRIM31 Polyclonal Antibody (HP111024)

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Overview
Catalog No.HP111024
Description
Anti-Human TRIM31 Polyclonal Antibody (HP111024) is a rabbit polyclonal antibody detecting TRIM31. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human TRIM31 (Met1-Gln145).
Target C6orf13, E3 ubiquitin-protein ligase TRIM31, EC:2.3.2.27, RNF, TRIM31, Tripartite motif-containing protein 31
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9BZY9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

E3 ubiquitin-protein ligase TRIM31 is a ~48 kDa protein. E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth.

1. Sugiura, T. et al. (2008) Journal of cellular biochemistry 105, 1081-91. PMID: 18773414
2. Song, H. et al. (2016) Nature communications 7, 13727. PMID: 27929086
3. Liu, B. et al. (2017) Nature immunology 18, 214-224. PMID: 27992402
Note For research use only
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Formula
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Anti-Human TRIM31 Polyclonal Antibody

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