Anti-Human USP37 Polyclonal Antibody (HA158014)

Name: Anti-Human USP37 Polyclonal Antibody
Brand: abinScience
SKU: HA158014
Price: 96 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

20ug
50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HA158014

설명

Anti-Human USP37 Polyclonal Antibody (HA158014) is a rabbit polyclonal antibody detecting USP37 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human USP37 (Met1-Arg106).

타겟

Ubiquitin carboxyl-terminal hydrolase 37, 3.4.19.12, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37, USP37, KIAA1594

정제

Purified by antigen affinity column.

등록번호

Q86T82

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Ubiquitin carboxyl-terminal hydrolase 37 (USP37) is a ~110 kDa protein. Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response. Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.

1. Yeh, C. et al. (2015) Current biology : CB 25, 2290-9. PMID: 26299517

2. Hernández-Pérez, S. et al. (2016) Molecular oncology 10, 1196-206. PMID: 27296872

3. Xiao, Z. et al. (2019) American journal of cancer research 9, 2749-2759. PMID: 31911859

4. Stromberg, BR. et al. (2021) The Journal of biological chemistry 297, 101184. PMID: 34509474

5. Huang, X. et al. (2011) Molecular cell 42, 511-23. PMID: 21596315

6. Wu, C. et al. (2021) Nucleic acids research 49, 11224-11240. PMID: 34606619

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-USP37 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate

참고 문헌

데이터시트

Anti-Human USP37 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human USP37 Polyclonal Antibody (HA158014)

개요

이미지

참고 문헌

데이터시트

SDS