Anti-Human WDR48 Polyclonal Antibody (HP117014)

Name: Anti-Human WDR48 Polyclonal Antibody
Brand: abinScience
SKU: HP117014
Price: 168 USD
Availability: InStock

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사양:

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100ug

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HP117014

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human WDR48 (Gly32-Lys358).

타겟

USP1-associated factor 1, WD repeat-containing protein 48, KIAA1449, WDR48, p80, WD repeat endosomal protein, UAF1

정제

Purified by antigen affinity column.

등록번호

Q8TAF3

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

WD repeat-containing protein 48 (WDR48) is a ~76 kDa protein. Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.

1. Cohn, MA. et al. (2007) Molecular cell 28, 786-97. PMID: 18082604

2. Cohn, MA. et al. (2009) The Journal of biological chemistry 284, 5343-51. PMID: 19075014

3. Yin, J. et al. (2015) Structure (London, England : 1993) 23, 2043-54. PMID: 26388029

4. Liang, F. et al. (2019) Nature communications 10, 2849. PMID: 31253762

5. Li, H. et al. (2016) Molecular cell 63, 249-260. PMID: 27373336

7. Gangula, NR. et al. (2013) The Journal of biological chemistry 288, 34545-54. PMID: 24145035

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human WDR48 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human WDR48 Polyclonal Antibody (HP117014)

개요

이미지

참고 문헌

데이터시트

SDS

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