Anti-Human YTHDF3 Polyclonal Antibody (HA146014)

Name: Anti-Human YTHDF3 Polyclonal Antibody
Brand: abinScience
SKU: HA146014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HA146014

설명

Anti-Human YTHDF3 Polyclonal Antibody (HA146014) is a rabbit polyclonal antibody detecting YTHDF3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human YTHDF3 (Gly416-Glu572).

타겟

YTH domain-containing family protein 3, DF3, YTHDF3

정제

Purified by antigen affinity column.

등록번호

Q7Z739

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

YTH domain-containing family protein 3 (YTHDF3) is a ~63 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs.

1. Shi, H. et al. (2017) Cell research 27, 315-328. PMID: 28106072

2. Li, A. et al. (2017) Cell research 27, 444-447. PMID: 28106076

3. Yang, Y. et al. (2017) Cell research 27, 626-641. PMID: 28281539

4. Zaccara, S. et al. (2020) Cell 181, 1582-1595.e18. PMID: 32492408

5. Dominissini, D. et al. (2012) Nature 485, 201-6. PMID: 22575960

6. Wang, X. et al. (2014) Nature 505, 117-20. PMID: 24284625

7. Ries, RJ. et al. (2019) Nature 571, 424-428. PMID: 31292544

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human YTHDF3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human YTHDF3 Polyclonal Antibody (HA146014)

개요

이미지

참고 문헌

데이터시트

SDS