Anti-Human ZNF410 Polyclonal Antibody (HP086014)

Name: Anti-Human ZNF410 Polyclonal Antibody
Brand: abinScience
SKU: HP086014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HP086014

설명

Anti-Human ZNF410 Polyclonal Antibody (HP086014) is a rabbit polyclonal antibody detecting ZNF410 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ZNF410 (Arg76-Ser191).

타겟

ZNF410, APA1, Another partner for ARF 1, Zinc finger protein 410, Zinc finger protein APA-1

정제

Purified by antigen affinity column.

등록번호

Q86VK4

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

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제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Zinc finger protein 410 (ZNF410) is a ~52 kDa protein. Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4.

1. Lan, X. et al. (2021) Molecular cell 81, 239-254.e8. PMID: 33301730

2. Vinjamur, DS. et al. (2021) Nature genetics 53, 719-728. PMID: 33859416

3. Benanti, JA. et al. (2002) Molecular and cellular biology 22, 7385-97. PMID: 12370286

4. Chen, Y. et al. (2018) Journal of cellular physiology 234, 606-618. PMID: 30078215

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human ZNF410 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human ZNF410 Polyclonal Antibody (HP086014)

개요

이미지

참고 문헌

데이터시트

SDS