Anti-IFN-alpha/beta R1 Polyclonal Antibody (HB823014)

Name: Anti-IFN-alpha/beta R1 Polyclonal Antibody
Brand: abinScience
SKU: HB823014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HB823014

설명

Anti-IFNAR1 Polyclonal Antibody (HB823014) is a rabbit polyclonal antibody detecting IFNAR1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human IFNAR1 (Lys28-Asn227).

타겟

Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1

정제

Purified by antigen affinity column.

등록번호

P17181

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Interferon alpha/beta receptor 1 (IFNAR1) is a ~63 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes.

1. Russell-Harde, D. et al. (1999) Biochemical and biophysical research communications 255, 539-44. PMID: 10049744

2. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120

3. Kumar, KG. et al. (2004) The Journal of biological chemistry 279, 46614-20. PMID: 15337770

4. Uzé, G. et al. (1990) Cell 60, 225-34. PMID: 2153461

5. Thomas, C. et al. (2011) Cell 146, 621-32. PMID: 21854986

6. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

7. Hernandez, N. et al. (2019) The Journal of experimental medicine 216, 2057-2070. PMID: 31270247

8. Gothe, F. et al. (2022) Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 74, 136-139. PMID: 33252644

9. Bastard, P. et al. (2022) The Journal of experimental medicine 219. PMID: 35442418

10. Abramovich, C. et al. (1994) The EMBO journal 13, 5871-7. PMID: 7813427

참고사항

For research use only.

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