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| 카탈로그 번호 | HV232014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-KCNK9 Polyclonal Antibody (HV232014) is a rabbit polyclonal antibody detecting KCNK9 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KCNK9 (Asn240-Val374). | ||||||||
| 타겟 | TASK3, KCNK9, Acid-sensitive potassium channel protein TASK-3, Potassium channel subfamily K member 9, Two pore K(+) channel KT3.2, TWIK-related acid-sensitive K(+) channel 3, Two pore potassium channel KT3.2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9NPC2 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Potassium channel subfamily K member 9 (KCNK9) is a ~42 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. 1. Chapman, CG. et al. (2000) Brain research. Molecular brain research 82, 74-83. PMID: 11042359 2. Vega-Saenz de Miera, E. et al. (2001) Journal of neurophysiology 86, 130-42. PMID: 11431495 3. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430 4. Lin, H. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2320345121. PMID: 38630723 5. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150 6. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818 | ||||||||
| 참고사항 | For research use only. |
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