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| 카탈로그 번호 | HV209014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-LAMTOR3 Polyclonal Antibody (HV209014) is a rabbit polyclonal antibody detecting LAMTOR3 in ELISA, IHC, WB. Suitable for Bovine, Danio rerio, Chicken, Human, and Mouse.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human LAMTOR3 (Met1-Ser124). | ||||||||
| 타겟 | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, Mitogen-activated protein kinase kinase 1-interacting protein 1, Ragulator complex protein LAMTOR3, LAMTOR3, MAP2K1IP1, MAPKSP1, MEK-binding partner 1, Mitogen-activated protein kinase scaffold protein 1, Mp1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9UHA4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ragulator complex protein LAMTOR3 is a ~13 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. 1. Sancak, Y. et al. (2010) Cell 141, 290-303. PMID: 20381137 2. Bar-Peled, L. et al. (2012) Cell 150, 1196-208. PMID: 22980980 3. de Araujo, MEG. et al. (2017) Science (New York, N.Y.) 358, 377-381. PMID: 28935770 4. Su, MY. et al. (2017) Molecular cell 68, 835-846.e3. PMID: 29107538 5. Zhang, T. et al. (2017) Nature communications 8, 1394. PMID: 29123114 6. Yonehara, R. et al. (2017) Nature communications 8, 1625. PMID: 29158492 7. Shen, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 9545-9550. PMID: 30181260 | ||||||||
| 참고사항 | For research use only. |
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