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| 카탈로그 번호 | MW444107 |
|---|---|
| 종 반응성 | Mouse |
| 응용 분야 | ELISA, FCM, Neutralization |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, lambda |
| 클론 ID | SAA2201 |
| 타겟 | C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P56484 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production. 1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461 2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588 3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Mouse CD198/CCR8 Antibody (SAA2201)
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