Anti-Mouse Endosialin/CD248 Recombinant Antibody (G78) (MV681207)

Name: Anti-Mouse Endosialin/CD248 Recombinant Antibody (G78)
Brand: abinScience
SKU: MV681207
Price: 191 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	MV681207
종 반응성	Human, Mouse
응용 분야	ELISA, FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2a, lambda
클론 ID	G78
테스트된 응용 분야	FCM
타겟	Endosialin, TEM1, CD164L1, Tumor endothelial marker 1, CD248
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q91V98
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	Endosialin (CD248) is a ~81 kDa protein. Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway. Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory responses in macrophages by favoring production of proinflammatory cytokines. 1. Opavsky, R. et al. (2001) The Journal of biological chemistry 276, 38795-807. PMID: 11489895 2. Naylor, AJ. et al. (2014) PloS one 9, e107146. PMID: 25243742 3. Benedet, PO. et al. (2024) EBioMedicine 99, 104906. PMID: 38061240 4. Hong, YK. et al. (2019) The Journal of investigative dermatology 139, 2204-2214.e7. PMID: 30986375 5. Kapopara, PR. et al. (2021) Journal of thrombosis and haemostasis : JTH 19, 1932-1947. PMID: 33830628 6. Cheng, TL. et al. (2021) Translational research : the journal of laboratory and clinical medicine 232, 150-162. PMID: 33737161
참고사항	For research use only.

이미지

Flow Cytometry

Flow-cytometry using anti-mouse CD248 antibody.CD248 Transfected CHO cells were stained with an irrelevant antibody (Blue Histogram) or an anti-mouse CD248 antibody monoclonal antibody (Catalog # MV681207 ,Green Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a FITC conjugated goat anti-mouse antibody (Catalog # MF690414) and cells analysed on a NovoCyte Flow Cytometer.

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