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| 카탈로그 번호 | MW810014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse COMP Polyclonal Antibody (MW810014) is a rabbit polyclonal antibody detecting COMP in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse COMP (Gly577-Val755). | ||||||||
| 타겟 | TSP5, Thrombospondin-5, COMP, Cartilage oligomeric matrix protein | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9R0G6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Cartilage oligomeric matrix protein (COMP) is a ~82 kDa protein. Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). 1. Li, C. et al. (2020) Nature communications 11, 3642. PMID: 32686688 | ||||||||
| 참고사항 | For research use only. |
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