Anti-Mouse CXCL10/IP-10 Polyclonal Antibody (MY524014)

Name: Anti-Mouse CXCL10/IP-10 Polyclonal Antibody
Brand: abinScience
SKU: MY524014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

MY524014

설명

Anti-Mouse CXCL10/IP-10 Polyclonal Antibody (MY524014) is a rabbit polyclonal antibody detecting IP-10 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse CXCL10/IP-10 (Ile22-Pro98).

타겟

C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, C7, Interferon-gamma induced protein CRG-2, Small-inducible cytokine B10, Cxcl10, Crg2, Ifi10, Inp10, Scyb10

정제

Purified by antigen affinity column.

등록번호

P17515

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site.

1. Gao, N. et al. (2017) Angiogenesis 20, 505-518. PMID: 28623423

2. Lindell, DM. et al. (2008) European journal of immunology 38, 2168-79. PMID: 18624292

3. Wuest, TR. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 7985-93. PMID: 19017990

4. Srivastava, R. et al. (2017) Journal of virology 91. PMID: 28468883

5. Rappert, A. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8500-9. PMID: 15456824

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Mouse CXCL10/IP-10 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse CXCL10/IP-10 Polyclonal Antibody (MY524014)

개요

이미지

참고 문헌

데이터시트

SDS