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| 카탈로그 번호 | MV388127 |
|---|---|
| 설명 |
Anti-Mouse FOXP3 Monoclonal Antibody (1A724 ), PE [1A724] (MV388127) is a mouse monoclonal antibody detecting Foxp3 in FCM. Suitable for Mouse.
Highlights
|
| 종 반응성 | Mouse |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | 1A724 |
| 타겟 | Forkhead box protein P3, Forkhead box protein P3 41 kDa form, Forkhead box protein P3, C-terminally processed, Foxp3, Scurfin |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q99JB6 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. _x005F_x005F_x000D_ _x005F_x005F_x000D_1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742 _x005F_x005F_x000D_
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2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 _x005F_x005F_x000D_
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3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 _x005F_x005F_x000D_
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4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049 _x005F_x005F_x000D_
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5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312 _x005F_x005F_x000D_ |
| 참고사항 | For research use only. |
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